MIC1 and MIC3

Toxoplasma gondii-Induced Activation of EGFR Prevents Autophagy Protein-Mediated Killing of the Parasite

Toxoplasma gondii resides in an intracellular compartment (parasitophorous vacuole) that excludes transmembrane molecules required for endosome-lysosome recruitment. Thus, the parasite survives by avoiding lysosomal degradation. However, autophagy can re-route the parasitophorous vacuole to the lysosomes and cause parasite killing. This raises the possibility that T. gondii may deploy a strateg...

Synergistic role of micronemal proteins in Toxoplasma gondii virulence

Apicomplexan parasites invade cells by a unique mechanism involving discharge of secretory vesicles called micronemes. Microneme proteins (MICs) include transmembrane and soluble proteins expressing different adhesive domains. Although the transmembrane protein TRAP and its homologues are thought to bridge cell surface receptors and the parasite submembranous motor, little is known about the fu...

Embeddings 2.0: The Lexicon as Memory MIC3 Working Group http://www-csli.stanford.edu/MIC3

Embeddings 2.0: The Lexicon as Memory MIC3 Working Group http://cis.lmu.de/schuetze/mic3

2 Schedule (tentative) 2.1 Tuesday morning Brief introductions (1 min / person; you can prepare one slide, but free form is fine) Presentations I • Hinrich Schütze (introduction to working group, basically this document, 15+5) • Jay McClelland (45+15) • Maja Rudolph: Probabilistic modeling perspective (15+5) (Rudolph et al., 2016) • Rami Al-Rfou (and Marc Pickett?): Application perspective (15+...

Mic1-3 Knockout Toxoplasma gondii is a good candidate for a vaccine against T. gondii-induced abortion in sheep

This study assessed the effectiveness of a mutant strain of Toxoplasma gondii (RH strain) lacking the mic1 and mic3 genes (Mic1-3KO) against Toxoplasma abortion in sheep. Ewes were inoculated subcutaneously with 10(5) Mic1-3KO tachyzoïtes in three independent experiments. Following vaccination, Mic1-3KO induced a mild febrile response and serum IgG antibodies, which persisted throughout the exp...